Description
NeuroScience - Calm CP with Phosphatidylserine & Banaba
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- Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*
- Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid): Corosolic acid selectively inhibits 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1), an enzyme that catalyzes the conversion of cortisone into cortisol [1,2].* In a randomized study, corosolic acid was shown to significantly lower blood glucose levels by 20-30% after two weeks [3].*
- Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions [4].* Phosphatidylserine is thought to interact with cell membranes in order to dampen hypothalamic signaling and regulate the stress response [5].*
- Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier [6].* Binds receptors that regulate temperature during sleep [7].*
- Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity [8-10].* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep [11-13].
- References: [1] Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15. [2] Patel H, et al. Arabian Journal of Chemistry. 2015. [3] Judy W, et al. J Ethnopharmacol. 2003;87(1):115-7. [4] Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8. [5] Glade M and Smith K. Nutrition. 2015;31(6):781-6. [6] Kawai N, et al. Amino Acids. 2012;42(6):2129-37. [7] Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
- [8] Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27. [9] Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96. [10] Kletke O, et al. PLoS One. 2013;8(4):e61733. [11] Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81. [12] Mohler H. Neuropharmacology. 2012;62(1):42-53. [13] Saper C, et al. Nature. 2005;437(7063):1257-63.
